New Horizons: Novel adrenal regenerative therapies

In this narrative review, the authors discuss potential role of novel regenerative therapies for treatment adrenal insufficiency, including gene therapy and cell replacement strategies. More specifically, heterogeneity in function patients with Addison disease, numerous case reports spontaneous remission. The cite recent studies showing that, shortly after onset residual might be restored using B-lymphocyte-depleting immunotherapy ACTH treatment. rationale is that stimulates differentiation persisting progenitor or stem cells, while B-cell depletion prevents destruction newly differentiated cells (1). Furthermore, turnover cortex limits time-span effectiveness (2). A more promising strategy transplantation, which potentially curative. Research foci include alternative sources, biomaterials have been developed to improve viability engineered upon implantation, cellular based on pluripotent (3).